Phenotypes Associated with This Genotype

Genotype
MGI:3662906

• Allelic Composition: Ret^tm1Kln/Ret^tm1Kln; Tg(Nes-cre)1Kln/0
• Genetic Background: involves: 129/Sv * BALB/c * C57BL/6 * CBA/J * SJL

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

nervous system

abnormal innervation pattern to muscle ( J:110955 )

• mutants have peroneal nerves (PN) of reduced length (~40% of control) at E11.5 and nerves are reduced in complexity at E12.5; diameter of peroneal nerve is also reduced

• phenotype at E12.5 is somewhat less severe than in Ret^tm1Kln; Tg(Pgk1-cre)1Lni mice

limbs/digits/tail

clubfoot ( J:110955 )

• clubbed feet are observed in mutants after birth

Mouse Models of Human Disease		DO ID	OMIM ID(s)	Ref(s)
clubfoot		DOID:11836	OMIM:119800	J:110955