Phenotypes Associated with This Genotype

Genotype
MGI:3663021

• Allelic Composition: Fas^lpr/Fas^lpr; Tg(Ins2-Fasl)24Ach/0
• Genetic Background: NOD.Cg-Fas^lpr Tg(Ins2-Fasl)24Ach

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

immune system

decreased susceptibility to autoimmune diabetes ( J:81416 )

• when mice are injected with islet-specific CD8+ T cells, 0/5 transgenic Fas-deficient mice become diabetic whereas 5/5 transgenic Fas-sufficient mice develop diabetes 5 days after transfer

Mouse Models of Human Disease		DO ID	OMIM ID(s)	Ref(s)
type 1 diabetes mellitus		DOID:9744	OMIM:222100	J:81416