Phenotypes Associated with This Genotype

Genotype
MGI:3663620

• Allelic Composition: Tg(APP695)3Dbo/0; Tg(PSEN1)5Dbo/0
• Genetic Background: involves: C3H/HeJ * C57BL/6J

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

nervous system

nervous system phenotype ( J:100961 )

N • no differences in neuron number in cingulate cortex relative to wild-type

amyloid beta deposits ( J:43788 , J:87691 , J:100961 )

• amyloid beta deposits found in cortex and hippocampus tissue from 9 and 12 month old mice and increase in number between 10 ans 12 months of age (J:43788)

• amyloid beta peptides AB1-40 and AB1-42 are codeposited (J:43788)

• ratio of amyloid beta peptide 40:42 is 1.75:1 (J:87691)

• exhibits a 50% increase in amyloid beta peptide 42 (J:87691)

• immunoreactive amyloid beta deposits are observed in the cingulate cortex in 12 month-old double transgenic mice; deposits are most evident in gray matter of cingulate and enthorhinal cortex, and to lesser extent in non-neuronal layers of the hippocampal formation (J:100961)

astrocytosis ( J:43788 )

• associated with dystropic neuritis in cortex and hippocampus

abnormal neuron morphology ( J:43788 )

• dystrophic neuritis associated with reactive gliosis in cortex and hippocampus

abnormal neuron physiology ( J:100961 )

• neurons in cingulate cortex display 3-fold elevation in phosphorylated tumor suppressor protein (pRb) and activated caspase-3 relative to wild-type neurons

homeostasis/metabolism

amyloid beta deposits ( J:43788 , J:87691 , J:100961 )

• amyloid beta deposits found in cortex and hippocampus tissue from 9 and 12 month old mice and increase in number between 10 ans 12 months of age (J:43788)

• amyloid beta peptides AB1-40 and AB1-42 are codeposited (J:43788)

• ratio of amyloid beta peptide 40:42 is 1.75:1 (J:87691)

• exhibits a 50% increase in amyloid beta peptide 42 (J:87691)

• immunoreactive amyloid beta deposits are observed in the cingulate cortex in 12 month-old double transgenic mice; deposits are most evident in gray matter of cingulate and enthorhinal cortex, and to lesser extent in non-neuronal layers of the hippocampal formation (J:100961)

Mouse Models of Human Disease		DO ID	OMIM ID(s)	Ref(s)
Alzheimer's disease		DOID:10652		J:43788
Alzheimer's disease 3		DOID:0110042	OMIM:607822	J:43788
Alzheimer's disease 4		DOID:0110040	OMIM:606889	J:43788