Phenotypes Associated with This Genotype

Genotype
MGI:3663621

• Allelic Composition: Tg(APP695)3Dbo/0
• Genetic Background: involves: C3H/HeJ * C57BL/6J

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

nervous system

nervous system phenotype ( J:43788 )

N • no immunoreactive amyloid beta deposits found in cortex or hippocampus from 12 month old mice as compared to double transgenic mice: Tg(APP695)3Dbo/0, Tg(PSEN1)5Dbo/0

amyloid beta deposits ( J:43788 , J:87691 )

• amyloid beta deposits observed in cortex and hippocampus of 18 and 20 month old mice (J:43788)

• ratio of amyloid beta peptide 40:42 is 3:1 (J:87691)

homeostasis/metabolism

amyloid beta deposits ( J:43788 , J:87691 )

• amyloid beta deposits observed in cortex and hippocampus of 18 and 20 month old mice (J:43788)

• ratio of amyloid beta peptide 40:42 is 3:1 (J:87691)

Mouse Models of Human Disease		DO ID	OMIM ID(s)	Ref(s)
Alzheimer's disease		DOID:10652		J:87691