Phenotypes Associated with This Genotype

Genotype
MGI:3663751

• Allelic Composition: Tg(APPswe,PSEN1dE9)85Dbo/0
• Genetic Background: involves: C3H/HeJ * C57BL/6J

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

nervous system

amyloid beta deposits ( J:87691 , J:139071 )

• plaques are abundant in hippocampus and cortex by 9 months of age (J:87691)

• occasional deposits can be found in mice as young as 6 months of age (J:87691)

• ratio of amyloid beta peptide 40:42 is 0.50:1 (J:87691)

• deposits observed in hippocampus by 6 months of age (J:139071)

reduced long-term potentiation ( J:139071 )

• transient long term potentiation (t-LTP) is reduced in transgenics and is age-independent

behavior/neurological

abnormal spatial reference memory ( J:139071 )

• transgenic mice exhibit a 4-5% higher preference for the arm of the radial arm water maze that held the platform on the previous day

• 13 month old transgenic mice commit more errors in the water maze than controls, at 7 months of age both groups test similarly

impaired coordination ( J:139071 )

• 14 month old transgenic mice exhibit a reduced ability to maintain balance on a rotarod

growth/size/body

decreased body weight ( J:139071 )

• at 14 months, transgenics weigh less than controls

homeostasis/metabolism

amyloid beta deposits ( J:87691 , J:139071 )

• plaques are abundant in hippocampus and cortex by 9 months of age (J:87691)

• occasional deposits can be found in mice as young as 6 months of age (J:87691)

• ratio of amyloid beta peptide 40:42 is 0.50:1 (J:87691)

• deposits observed in hippocampus by 6 months of age (J:139071)

Mouse Models of Human Disease		DO ID	OMIM ID(s)	Ref(s)
Alzheimer's disease		DOID:10652		J:87691 , J:113200
Alzheimer's disease 3		DOID:0110042	OMIM:607822	J:87691 , J:113200