Phenotypes Associated with This Genotype

Genotype
MGI:3664614

• Allelic Composition: Lrp5^tm1Kry/Lrp5⁺
• Genetic Background: either: (involves: 129S1/Sv * 129X1/SvJ) or (involves: 129S1/Sv * 129X1/SvJ * C57BL/6J)

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

Abnormal osteogenesis in Lrp5^tm1Kry/Lrp5⁺ and Lrp5^tm1Kry/Lrp5^tm1Kry mice

skeleton

abnormal osteoblast physiology ( J:75973 )

• in 6-month-old mice, a 2-fold decrease in bone formation rate (BFR) is observed; similar results are seen in 2- and 4-month-old animals (88.6 um³/year vs 60.5 um³/year)

decreased bone volume ( J:75973 )

• heterozygotes have significantly decreased bone volume compared to wild-type

decreased bone mass ( J:75973 )

• less severe than in homozygotes

abnormal bone ossification ( J:75973 )

• bone formation is abnormal, but bone resorption does not appear to be affected

delayed bone ossification ( J:75973 )

• delay is milder in heterozygotes

cellular

abnormal osteoblast physiology ( J:75973 )

• in 6-month-old mice, a 2-fold decrease in bone formation rate (BFR) is observed; similar results are seen in 2- and 4-month-old animals (88.6 um³/year vs 60.5 um³/year)

Mouse Models of Human Disease		DO ID	OMIM ID(s)	Ref(s)
osteoporosis-pseudoglioma syndrome		DOID:0060849	OMIM:259770	J:75973