Phenotypes Associated with This Genotype

Genotype
MGI:3664938

hm1

• Allelic Composition: Add2^tm1Llp/Add2^tm1Llp
• Genetic Background: B6.129S4-Add2^tm1Llp/LlpJ

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

behavior/neurological

abnormal contextual conditioning behavior ( J:98208 )

• exhibit impaired performance on the contextual fear conditioning task, showing decreased freezing in response to the context-paired previously with foot shock cue

abnormal cued conditioning behavior ( J:98208 )

• exhibit impaired performance on cued fear conditioning task showing decreased freezing in response to the shock-paired auditory cue

abnormal spatial learning ( J:98208 )

• exhibit impaired performance in the water maze as shown by increased travel distance before finding the platform and slightly longer time to find the platform on the second and subsequent training days

• in a probe trial, spend equivalent amounts of time in each quadrant compared to wild-type which spend 50% of the time in the quadrant containing the platform

nervous system

impaired synaptic plasticity ( J:98208 )

• CA1 short- and long-term synaptic plasticity is impaired, with significantly stronger input-output relationships in hippocampal slices

abnormal CNS synaptic transmission ( J:98208 )

reduced long-term potentiation ( J:98208 )

• show impaired tetanic long-term potentiation in the SC-CA1 hippocampal circuit

increased post-tetanic potentiation ( J:98208 )

• immediately after two 1 s trains of 100 Hz stimulation, post-tetanic potential is slightly more robust than in wild-type hippocampal slices, and responses decay to baseline within 90 min while they remain potentiated for the duration of the experiment in wild-type

enhanced paired-pulse facilitation ( J:98208 )

• exhibit slightly enhanced paired-pulse facilitation at the 150s interstimulus interval