Phenotypes Associated with This Genotype

Genotype
MGI:3665287

• Allelic Composition: Tg(PRNP-APPSweInd)8Dwst/?
• Genetic Background: involves: 129S6/SvEvTac

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

nervous system

amyloid beta deposits ( J:113199 )

• observed at 16 and 20 weeks of age in hippocampus and cortex

• level of brain amyloid beta peptide 42 is predominant over 40; levels increase dramatically after 16 weeks of age

homeostasis/metabolism

amyloid beta deposits ( J:113199 )

• observed at 16 and 20 weeks of age in hippocampus and cortex

• level of brain amyloid beta peptide 42 is predominant over 40; levels increase dramatically after 16 weeks of age

increased circulating triglyceride level ( J:113199 )

• elevated plasma triglyceride levels observed between 9 and 15 weeks of age

increased circulating VLDL triglyceride level ( J:113199 )

• VLDL production rates are increased as early as 9 weeks of age and remain elevated up to 22 weeks of age

• plasma free fatty acid levels were unchanged

Mouse Models of Human Disease		DO ID	OMIM ID(s)	Ref(s)
Alzheimer's disease		DOID:10652		J:113199