Phenotypes Associated with This Genotype

Genotype
MGI:3665560

cn5

• Allelic Composition: Smo^tm1Amc/Smo^tm2Amc; Tg(Nes-cre)1Kln/0
• Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * SJL * Swiss Webster

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

mortality/aging

postnatal lethality, incomplete penetrance ( J:108507 )

• about 10% of mice survive to 3 weeks of age

nervous system

decreased brain size ( J:108507 )

• overall size of mutant brains is smaller than wild-type

abnormal cerebellum morphology ( J:108507 )

• four principal fissures are very shallow

abnormal cerebellar foliation ( J:108507 )

• in lateral regions, foliation is limited to slight indentations only in central and posterior regions

small cerebellum ( J:108507 )

• at E16.5, cerebella appear grossly normal, but reduced in size

• at P21, cerebella shows more pronounced reduction in size vs wild-type

• AP axis is more dramatically reduced than ML axis