Phenotypes Associated with This Genotype

Genotype
MGI:3665566

• Allelic Composition: F11^tm1Gjb/F11^tm1Gjb
• Genetic Background: involves: 129X1/SvJ * C57BL/6

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

nervous system

decreased susceptibility to ischemic brain injury ( J:123758 )

• after transient middle cerebral artery occlusion, the volume of infarcted brain is less than in controls

• reduced fibrin formation in ischemic vessels

homeostasis/metabolism

decreased platelet aggregation ( J:100529 )

• defect in the formation and stabilization of platelet-rich occlusive thrombi after injury

increased partial thromboplastin time ( J:40270 )

• activated partial thromboplastin times markedly prolonged (moderately so in heterozygotes)

• tail bleeding times slightly but not significantly increased over controls

decreased susceptibility to ischemic brain injury ( J:123758 )

• after transient middle cerebral artery occlusion, the volume of infarcted brain is less than in controls

• reduced fibrin formation in ischemic vessels

hematopoietic system

decreased platelet aggregation ( J:100529 )

• defect in the formation and stabilization of platelet-rich occlusive thrombi after injury

Mouse Models of Human Disease		DO ID	OMIM ID(s)	Ref(s)
factor XI deficiency		DOID:2229	OMIM:612416	J:40270