Phenotypes Associated with This Genotype

Genotype
MGI:3686788

cx1

• Allelic Composition: Mc1r^e/Mc1r^e; Xpc^tm1Brd/Xpc^tm1Brd; Tg(KRT14-Kitl)1Takk/0
• Genetic Background: involves: 129S7/SvEvBrd * C57BL/6 * SJL

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

growth/size/body

weight loss ( J:112959 )

• vehicle-treated mutants show weight loss, indicative of failure to thrive, compared to forskolin-treated animals

neoplasm

increased tumor incidence ( J:112959 )

• vehicle-treated mutant controls develop tumors more rapidly (11 tumors ~4 weeks after 20 weeks of UV-B exposure) compared to forskolin-treated mice (6 tumors, onset ~25 weeks)

• other types of tumors are found in vehicle-treated mice (3/11); 2/9 mice develop multiple tumors

increased squamous cell carcinoma incidence ( J:112959 )

• tumors in vehicle-treated mutants are mainly this type (6/11) while forskolin-treated mice develop only this type

integument

thick epidermis ( J:112959 )

• vehicle-treated mutants show significant sun damage after 20 weeks of UV-B exposure including profound epidermal thickening while forskoling treatment prevented damage

skin lesions ( J:112959 )

• vehicle-treated mutants show evidence of sun damage like scarring after 20 weeks of UV-B exposure while forskolin treatment prevented damage