Phenotypes Associated with This Genotype

Genotype
MGI:3686900

• Allelic Composition: Slc12a5^tm1Dlp/Slc12a5⁺
• Genetic Background: involves: C57BL/6J

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

behavior/neurological

increased susceptibility to pharmacologically induced seizures ( J:113307 )

• about 2-fold increase in sensitivity to pentylenetetrazole induced epileptic seizures

nervous system

increased susceptibility to pharmacologically induced seizures ( J:113307 )

• about 2-fold increase in sensitivity to pentylenetetrazole induced epileptic seizures

abnormal summary potential ( J:113307 )

• at 10 to 14 days of age, hippocampal slices stimulated at a 0.1 Hz display multiple population spikes, unlike wild-type mice which display a single population spike

• however, the amplitude of the shortest latency spike is similar to wild-type

Mouse Models of Human Disease		DO ID	OMIM ID(s)	Ref(s)
epilepsy		DOID:1826		J:113307