Phenotypes for H2 Rag1 Tg(TcraBDC12-4.1)10Jos Tg(TcrbBDC12-4.1)82Gse MGI:3687165 MGI Mouse

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Phenotypes Associated with This Genotype

Allelic Composition	H2^g7/H2^q Rag1^tm1Mom/Rag1^tm1Mom Tg(TcraBDC12-4.1)10Jos/0 Tg(TcrbBDC12-4.1)82Gse/0
Genetic Background	involves: 129S7/SvEvBrd * C57BL/6 * FVB * NOD

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
H2^g7 mutation (24 available); any H2 mutation (282 available)
H2^q mutation (5 available); any H2 mutation (282 available)
Rag1^tm1Mom mutation (49 available); any Rag1 mutation (123 available)
Tg(TcraBDC12-4.1)10Jos mutation (2 available)
Tg(TcrbBDC12-4.1)82Gse mutation (2 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

immune system

increased susceptibility to autoimmune diabetes ( J:111874 )

• 15% of mice heterozygous for the H2 alleles develop diabetes by 44 weeks

Mouse Models of Human Disease		DO ID	OMIM ID(s)	Ref(s)
type 1 diabetes mellitus		DOID:9744	OMIM:222100	J:111874

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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