Phenotypes for H2 Ins2 Rag1 Tg(TcraBDC12-4.1)10Jos Tg(TcrbBDC12-4.1)82Gse MGI:3687167 MGI Mouse

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Phenotypes Associated with This Genotype

Allelic Composition	H2^g7/H2^g7 Ins2^tm1Jja/Ins2^tm1Jja Rag1^tm1Mom/Rag1^tm1Mom Tg(TcraBDC12-4.1)10Jos/0 Tg(TcrbBDC12-4.1)82Gse/0
Genetic Background	involves: 129S2/SvPas * 129S7/SvEvBrd * C57BL/6 * FVB * NOD

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
H2^g7 mutation (24 available); any H2 mutation (282 available)
Ins2^tm1Jja mutation (4 available); any Ins2 mutation (93 available)
Rag1^tm1Mom mutation (49 available); any Rag1 mutation (123 available)
Tg(TcraBDC12-4.1)10Jos mutation (2 available)
Tg(TcrbBDC12-4.1)82Gse mutation (2 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

homeostasis/metabolism

increased circulating glucose level ( J:111874 )

immune system

increased susceptibility to autoimmune diabetes ( J:111874 )

• mice develop diabetes (blood glucose >250 ml/dl) more rapidly than transgenic Rag1-null, Ins2-sufficient mice

Mouse Models of Human Disease		DO ID	OMIM ID(s)	Ref(s)
type 1 diabetes mellitus		DOID:9744	OMIM:222100	J:111874

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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