Phenotypes Associated with This Genotype

Genotype
MGI:3687232

cn4

• Allelic Composition: Mapk1^tm1Hed/Mapk1^tm1Hed; Tg(Lck-cre)1Cwi/0
• Genetic Background: involves: C57BL/6 * DBA/2

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

immune system

decreased T cell proliferation ( J:113280 )

• thymocytes display normal or slightly enhanced proliferation in vivo

decreased double-positive T cell number ( J:113280 )

• total number of double-positive (DP) thymocytes is reduced by 30%

abnormal T cell subpopulation ratio ( J:113280 )

• there is a substantial increase in number of DN3 thymocytes over DN4, consistent with partial block in maturation

hematopoietic system

decreased T cell proliferation ( J:113280 )

• thymocytes display normal or slightly enhanced proliferation in vivo

decreased double-positive T cell number ( J:113280 )

• total number of double-positive (DP) thymocytes is reduced by 30%

abnormal T cell subpopulation ratio ( J:113280 )

• there is a substantial increase in number of DN3 thymocytes over DN4, consistent with partial block in maturation

cellular

decreased T cell proliferation ( J:113280 )

• thymocytes display normal or slightly enhanced proliferation in vivo