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Phenotypes Associated with This Genotype
Genotype
MGI:3687234
cn1
Allelic
Composition		 Mapk1tm1Hed/Mapk1tm1Hed
Mapk3tm1Gpg/Mapk3tm1Gpg
Tg(Lck-cre)1Cwi/0
Genetic
Background		 involves: 129/Sv * C57BL/6 * DBA/2
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Mapk1tm1Hed mutation (0 available); any Mapk1 mutation (43 available)
Mapk3tm1Gpg mutation (1 available); any Mapk3 mutation (26 available)
Tg(Lck-cre)1Cwi mutation (3 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
immune system
abnormal T cell proliferation ( J:113280 )
• thymocytes display normal or slightly enhanced proliferation in vivo
small thymus ( J:113280 )
• some mice have very small thymuses (13 x 106 cells) with few DN4 cells, but some have larger thymuses (115 x 106 cells)
decreased thymocyte number ( J:113280 )
• total thymocyte number is decreased >3-fold compared to wild-type
increased double-positive T cell number ( J:113280 )
• mice have a substantial population of double-positive T cells

hematopoietic system
abnormal T cell proliferation ( J:113280 )
• thymocytes display normal or slightly enhanced proliferation in vivo
small thymus ( J:113280 )
• some mice have very small thymuses (13 x 106 cells) with few DN4 cells, but some have larger thymuses (115 x 106 cells)
decreased thymocyte number ( J:113280 )
• total thymocyte number is decreased >3-fold compared to wild-type
increased double-positive T cell number ( J:113280 )
• mice have a substantial population of double-positive T cells

endocrine/exocrine glands
small thymus ( J:113280 )
• some mice have very small thymuses (13 x 106 cells) with few DN4 cells, but some have larger thymuses (115 x 106 cells)
decreased thymocyte number ( J:113280 )
• total thymocyte number is decreased >3-fold compared to wild-type

cellular
abnormal T cell proliferation ( J:113280 )
• thymocytes display normal or slightly enhanced proliferation in vivo

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
03/18/2025
MGI 6.24 		The Jackson Laboratory