Phenotypes Associated with This Genotype

Genotype
MGI:3687235

cn5

• Allelic Composition: Mapk1^tm1Hed/Mapk1^tm1Hed; Tg(Cd4-cre)1Cwi/0
• Genetic Background: involves: C57BL/6 * DBA/2

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

immune system

abnormal positive T cell selection ( J:113280 )

• there is a significant reduction in percentage of positively-selected thymocytes

increased double-positive T cell number ( J:113280 )

• increase in double positive thymocytes and compensatory decrease in single positive numbers restores thymic cellularity compare to Mapk1/Lck-cre transgenics

decreased CD4-positive, alpha-beta T cell number ( J:113280 )

• number of CD4 single positive thymocytes is decreased compared to wild-type

decreased CD8-positive, alpha-beta T cell number ( J:113280 )

• number of CD8 single positive thymocytes is decreased compared to wild-type

hematopoietic system

abnormal positive T cell selection ( J:113280 )

• there is a significant reduction in percentage of positively-selected thymocytes

increased double-positive T cell number ( J:113280 )

• increase in double positive thymocytes and compensatory decrease in single positive numbers restores thymic cellularity compare to Mapk1/Lck-cre transgenics

decreased CD4-positive, alpha-beta T cell number ( J:113280 )

• number of CD4 single positive thymocytes is decreased compared to wild-type

decreased CD8-positive, alpha-beta T cell number ( J:113280 )

• number of CD8 single positive thymocytes is decreased compared to wild-type