About   Help   FAQ
Phenotypes Associated with This Genotype
Genotype
MGI:3687236
cn2
Allelic
Composition		 Mapk1tm1Hed/Mapk1tm1Hed
Mapk3tm1Gpg/Mapk3tm1Gpg
Tg(Cd4-cre)1Cwi/0
Genetic
Background		 involves: 129/Sv * C57BL/6 * DBA/2
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Mapk1tm1Hed mutation (0 available); any Mapk1 mutation (42 available)
Mapk3tm1Gpg mutation (1 available); any Mapk3 mutation (27 available)
Tg(Cd4-cre)1Cwi mutation (12 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
hematopoietic system
abnormal positive T cell selection ( J:113280 )
• there is a significant reduction in percentage of positively-selected thymocytes but there is still a substantial population of single positive thymocytes

immune system
abnormal positive T cell selection ( J:113280 )
• there is a significant reduction in percentage of positively-selected thymocytes but there is still a substantial population of single positive thymocytes

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
Warranty Disclaimer, Privacy Notice, Licensing, & Copyright
Send questions and comments to User Support. 		last database update
01/06/2026
MGI 6.24 		The Jackson Laboratory