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Phenotypes Associated with This Genotype
Genotype
MGI:3687238
cn3
Allelic
Composition		 Mapk1tm1Hed/Mapk1tm1Hed
Mapk3tm1Gpg/Mapk3tm1Gpg
Tg(Cd4-cre)1Cwi/0
Tg(TcrAND)53Hed/0
Genetic
Background		 involves: 129/Sv * C57BL/6 * DBA/2 * SJL
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Mapk1tm1Hed mutation (0 available); any Mapk1 mutation (43 available)
Mapk3tm1Gpg mutation (1 available); any Mapk3 mutation (26 available)
Tg(Cd4-cre)1Cwi mutation (10 available)
Tg(TcrAND)53Hed mutation (2 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
immune system
abnormal positive T cell selection ( J:113280 )
• positive selection is diminished significantly
abnormal T cell subpopulation ratio ( J:113280 )
• CD4 to CD8 ratio (% of mature CD4 and CD8 T cells) is 24 compared to 257 in non transgenic littermates

hematopoietic system
abnormal positive T cell selection ( J:113280 )
• positive selection is diminished significantly
abnormal T cell subpopulation ratio ( J:113280 )
• CD4 to CD8 ratio (% of mature CD4 and CD8 T cells) is 24 compared to 257 in non transgenic littermates

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
03/18/2025
MGI 6.24 		The Jackson Laboratory