About   Help   FAQ
Phenotypes Associated with This Genotype
Genotype
MGI:3687239
cn6
Allelic
Composition		 Mapk1tm1Hed/Mapk1tm1Hed
Tg(Lck-cre)1Cwi/0
Tg(TcrAND)53Hed/0
Genetic
Background		 involves: C57BL/6 * DBA/2 * SJL
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Mapk1tm1Hed mutation (0 available); any Mapk1 mutation (43 available)
Tg(Lck-cre)1Cwi mutation (3 available)
Tg(TcrAND)53Hed mutation (2 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
immune system
abnormal positive T cell selection ( J:113280 )
• positive selection is diminished significantly
abnormal T cell subpopulation ratio ( J:113280 )
• CD4 to CD8 ratio (% of mature CD4 and CD8 T cells) is 20 compared to 257 in non transgenic littermates

hematopoietic system
abnormal positive T cell selection ( J:113280 )
• positive selection is diminished significantly
abnormal T cell subpopulation ratio ( J:113280 )
• CD4 to CD8 ratio (% of mature CD4 and CD8 T cells) is 20 compared to 257 in non transgenic littermates

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
Warranty Disclaimer, Privacy Notice, Licensing, & Copyright
Send questions and comments to User Support. 		last database update
03/18/2025
MGI 6.24 		The Jackson Laboratory