Phenotypes Associated with This Genotype

Genotype
MGI:3688741

• Allelic
  Composition
• Genetic Background: TALLYHO/JngJ

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

homeostasis/metabolism

increased circulating glucose level ( J:114221 )

• male plasma glucose levels begin increasing by 8 weeks of age and peak (300-400 mg/dl) at 14 weeks

• female mice are normoglycemic

hyperglycemia ( J:114221 )

• only males become hyperglycemic although variability exists between litters

increased circulating insulin level ( J:114221 )

• at 4 weeks of age, mice of both sexes are hyperinsulinemic compared to C57BL/6J mice

• although female mice maintain stable levels, male plasma insulin levels peak (12 ng/ml) between 8-12 weeks

increased circulating leptin level ( J:114221 )

• at 4 weeks of age, mice of both sexes are hyperleptinemic compared to C57BL/6J mice

increased circulating cholesterol level ( J:114221 )

• at 4 weeks of age, mice of both sexes are hypercholesterolemic compared to C57BL/6J mice

increased circulating triglyceride level ( J:114221 )

• at 4 weeks of age, mice of both sexes are hypertriglyceridemic compared to C57BL/6J mice

• males exhibit a higher triglyceride level than females beginning at 6 weeks; levels remain elevated (>600 mg/dl) to at least 16 weeks of age

impaired glucose tolerance ( J:114221 )

• males exhibit impaired glucose tolerance by 8 weeks of age as measured by IPGTT

• females exhibit normal glucose tolerance

insulin resistance ( J:114221 )

• at 8 weeks of age fasting and post-glucose challenge insulin levels are higher in TALLYHO/JngJ males than in C57BL/6J males, however, by 16 weeks total insulin secretion in response to glucose is similar between the two strains

endocrine/exocrine glands

abnormal pancreatic islet morphology ( J:114221 )

• islets in 16 week old males exhibit granulation, some vacuolation, scattered apoptotic cells and occasional mild fibrosis

enlarged pancreatic islets ( J:114221 )

• at 4 weeks of age, mice of both sexes exhibit larger islet size as compared to C57BL/6J mice

pancreas fibrosis ( J:114221 )

• mild fibrosis present in some 16 week old males

growth/size/body

increased body weight ( J:114221 )

• increased body weight as compared to C57BL/6J mice

muscle

abnormal muscle cell glucose uptake ( J:114221 )

• glucose uptake in the soleus muscle is reduced in TALLYHO/JngJ males as compared to C57BL/6J males

cellular

abnormal muscle cell glucose uptake ( J:114221 )

• glucose uptake in the soleus muscle is reduced in TALLYHO/JngJ males as compared to C57BL/6J males