Phenotypes Associated with This Genotype

Genotype
MGI:3689381

• Allelic Composition: Cftr^tm3Mrc/Cftr^tm3Mrc
• Genetic Background: B6.129S6-Cftr^tm3Mrc

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

digestive/alimentary system

intestinal obstruction ( J:112450 )

• develop intestinal blockage when fed a normal (solid) diet

growth/size/body

postnatal growth retardation ( J:112450 )

• weighed significantly less (P 0.05) than homozygote wild-type controls at 14 and 21 days of age

immune system

lung inflammation ( J:112450 )

• increased inflammatory response to chronic Pseudomonas aeruginosa infection, identical to that in Cftr^tm1Unc homozygotes

increased susceptibility to bacterial infection induced morbidity/mortality ( J:112450 )

• reduced ability to respond to lung infection elicited with Pseudomonas aeruginosa- laden agarose beads

mortality/aging

increased susceptibility to bacterial infection induced morbidity/mortality ( J:112450 )

• reduced ability to respond to lung infection elicited with Pseudomonas aeruginosa- laden agarose beads

respiratory system

lung inflammation ( J:112450 )

• increased inflammatory response to chronic Pseudomonas aeruginosa infection, identical to that in Cftr^tm1Unc homozygotes

decreased respiratory epithelial chloride transmembrane transport ( J:112450 )

• after treatment with a chloride-depleted solution with amiloride and forskolin, the nasal potential difference (PD) was significantly different between control mice and homozygous mice

Mouse Models of Human Disease		DO ID	OMIM ID(s)	Ref(s)
cystic fibrosis		DOID:1485	OMIM:219700	J:112450