Phenotypes Associated with This Genotype

Genotype
MGI:3689843

hm1

• Allelic Composition: Ptk2^tm1Imeg/Ptk2^tm1Imeg
• Genetic Background: CBA.Cg-Ptk2^tm1Imeg

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

mortality/aging

embryonic lethality between somite formation and embryo turning, complete penetrance ( J:82150 )

• die at E8.5

embryo

absent vitelline blood vessels ( J:82150 )

• exhibit absence of vascular structures in the yolk sac

cardiovascular system

abnormal blood vessel morphology ( J:82150 )

• exhibit impaired development of the vasculature system

abnormal vascular endothelial cell development ( J:82150 )

• embryoid bodies differentiating from homozygotes do not develop Pecam1 (CD31)-positive interconnecting vascular channels, indicating inability of endothelial cells to organize into a vascular network, however endothelial cell differentiation is not impaired

absent vitelline blood vessels ( J:82150 )

• exhibit absence of vascular structures in the yolk sac

hemorrhage ( J:82150 )

• 80% exhibit hemorrhage in the placental cone and extraembryonic structures