Phenotypes Associated with This Genotype

Genotype
MGI:3689926

• Allelic Composition: Igh^{tm1.1(Igh564)Tik}/Igh^{tm1.1(Igh564)Tik}; Igk^{tm1(Igk564)Tik}/Igk^{tm1(Igk564)Tik}
• Genetic Background: B6.129S4-Igk^{tm1(Igk564)Tik} Igh^{tm1(Igh564)Tik}

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

renal/urinary system

glomerulonephritis ( J:113555 )

• mutant mice kidney changes consistent with those seen in mesangioproliferative glomerulonephropathies in human

abnormal podocyte morphology ( J:113555 )

• mild basement membrane thickening

podocyte foot process effacement ( J:113555 )

• segmental epithelial cell foot process effacement

abnormal glomerular mesangium morphology ( J:113555 )

• expansion of the glomerular mesangium by increased mesangial cells, matrix, and numerous electron dense deposits

increased mesangial cell number ( J:113555 )

expanded mesangial matrix ( J:113555 )

immune system

glomerulonephritis ( J:113555 )

• mutant mice kidney changes consistent with those seen in mesangioproliferative glomerulonephropathies in human

cellular

increased mesangial cell number ( J:113555 )

Mouse Models of Human Disease		DO ID	OMIM ID(s)	Ref(s)
systemic lupus erythematosus		DOID:9074	OMIM:152700 OMIM:300809 OMIM:605480 OMIM:608437 OMIM:609903 OMIM:609939 OMIM:610065 OMIM:610066 OMIM:612254 OMIM:612378 OMIM:613145 OMIM:614420	J:113555