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Phenotypes Associated with This Genotype
Genotype
MGI:3691216
ht1
Allelic
Composition		 Nit1tm1Hbn/Nit1tm1.1Hbn
Genetic
Background		 involves: 129X1/SvJ * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Nit1tm1.1Hbn mutation (0 available); any Nit1 mutation (15 available)
Nit1tm1Hbn mutation (0 available); any Nit1 mutation (15 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
neoplasm
increased incidence of tumors by chemical induction ( J:115052 )
• mice receiving 6 intragastric doses of N-nitrosomethylbenzylamine (NMBA) over 3 weeks show increased incidence of forestomach papillomas and dysplasias (carcinomas in situ) compared to controls; number of papillomas and dysplasias is ~equivalent to numbers in Fhit-deficient mice

homeostasis/metabolism
increased incidence of tumors by chemical induction ( J:115052 )
• mice receiving 6 intragastric doses of N-nitrosomethylbenzylamine (NMBA) over 3 weeks show increased incidence of forestomach papillomas and dysplasias (carcinomas in situ) compared to controls; number of papillomas and dysplasias is ~equivalent to numbers in Fhit-deficient mice

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
12/10/2024
MGI 6.24 		The Jackson Laboratory