Phenotypes Associated with This Genotype

Genotype
MGI:3691218

cn2

• Allelic Composition: Nit1^tm1Hbn/Nit1^tm1Hbn
• Genetic Background: involves: 129X1/SvJ * C57BL/6

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

cellular

abnormal cell morphology ( J:115052 )

• cells are transfected with a retroviral cre to produce Nit1-deficient cells; Nit1-null cells have round and compact shapes, loss of lobular structure, higher cell density with increased S and G2/M cell populations, and >3-fold higher clonogenicity compared to cells not treated with cre recombinase

decreased cellular sensitivity to gamma-irradiation ( J:115052 )

• after treatment with mitomycin C (MMC) or UV-C light, Nit1-deficient cells show enhanced survival compared to Nit1-sufficient cells