Phenotypes Associated with This Genotype

Genotype
MGI:3691220

cn3

• Allelic Composition: Nit1^tm1Hbn/Nit1^tm1Hbn; Tg(Wap-cre)11738Mam/0
• Genetic Background: involves: 129X1/SvJ * C57BL/6 * SJL

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

endocrine/exocrine glands

abnormal branching of the mammary ductal tree ( J:115052 )

♀ • there is only a small significant difference in number of branch points during pregnancy

♀ • at mid-pregnant stages (day13 and 16), number of endbuds is significantly increased compared to controls

♀ • null mammary glands show an increase in ductal structures; lobuloalveolar structures are better developed at later times during pregnancy compared to controls

integument

abnormal branching of the mammary ductal tree ( J:115052 )

♀ • there is only a small significant difference in number of branch points during pregnancy

♀ • at mid-pregnant stages (day13 and 16), number of endbuds is significantly increased compared to controls

♀ • null mammary glands show an increase in ductal structures; lobuloalveolar structures are better developed at later times during pregnancy compared to controls