Phenotypes Associated with This Genotype

Genotype
MGI:3691280

• Allelic Composition: Myh6^tm1Ces/Myh6^tm1Ces
• Genetic Background: involves: 129S/SvEv * 129X1/SvJ

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

cardiovascular system

dilated heart left ventricle ( J:114549 )

dilated cardiomyopathy ( J:114549 )

• progress rapidly to dilated cardiomyopathy, however do not exhibit myofibrillar disarray or fibrosis

decreased cardiac muscle contractility ( J:114549 )

• develop contractile dysfunction and reduced fractional shortening at around 12 weeks of age

muscle

dilated cardiomyopathy ( J:114549 )

• progress rapidly to dilated cardiomyopathy, however do not exhibit myofibrillar disarray or fibrosis

decreased cardiac muscle contractility ( J:114549 )

• develop contractile dysfunction and reduced fractional shortening at around 12 weeks of age

Mouse Models of Human Disease		DO ID	OMIM ID(s)	Ref(s)
dilated cardiomyopathy		DOID:12930	OMIM:PS115200	J:114549