Phenotypes Associated with This Genotype

Genotype
MGI:3692535

cn8

• Allelic Composition: Mc4r^tm1Lowl/Mc4r^tm1Lowl; Tg(Sim1-cre)1Lowl/0
• Genetic Background: involves: 129S4/SvJae * C57BL/6J * FVB

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

growth/size/body

growth/size/body region phenotype ( J:115192 )

N • at 12 weeks, transgenic mice and wild-type littermates have the same snout-anus length, compared to increased length observed in nontransgenic Mc4r^tm1Lowl mice

increased lean body mass ( J:115192 )

• transgenic mice have increased lean mass compared with wild-type littermates, but significantly decreased lean mass compared to Mc4r^tm1Lowl littermates

increased body weight ( J:115192 )

• transgenic mice have increased fat mass compared with wild-type littermates, but significantly decreased fat mass compared to Mc4r^tm1Lowl littermates

obese ( J:115192 )

• at 12 weeks of age, male and female mutants have only 37% and 46% respectively, of the obesity observed in mice homozygous for Mc4r disruption

homeostasis/metabolism

abnormal oxygen consumption ( J:115192 )

• mice do not show an increase in oxygen consumption from stimulation by MTII as wild-type mice do

decreased oxygen consumption ( J:115192 )

• oxygen consumption is reduced in the dark and light cycles compared to wild-type and is similar to Mc4r^tm1Lowl homozygotes

behavior/neurological

behavior/neurological phenotype ( J:115192 )

N • transgenic mice are obese, yet show food intake comparable to wild-type mice at 11 weeks of age

abnormal food intake ( J:115192 )

• when treated with MTII an Mc4r inhibitor, wild-type mice show a 50% reduction in food intake, while transgenic mice display no effect on intake