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Phenotypes Associated with This Genotype
Genotype
MGI:3692743
Allelic
Composition		 Gfaptm3Mes/Gfap+
Genetic
Background		 involves: 129S6/SvEvTac * 129S7/SvEvBrd * FVB/N
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Gfaptm3Mes mutation (1 available); any Gfap mutation (48 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
growth/size/body
decreased body size ( J:114689 )

nervous system
abnormal astrocyte morphology ( J:114689 )
• develop Rosenthal fibers, especially within the hippocampus, olfactory bulb, corpus callosum, and rostral extension, as well as in subpial, perivascular and periventricular regions
• exhibit fewer Rosenthal fibers than seen in heterozygous Gfaptm2Hgmn mutants

Mouse Models of Human Disease
 DO ID OMIM ID(s) Ref(s)
Alexander disease DOID:4252 OMIM:203450
 J:114689

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
11/12/2024
MGI 6.24 		The Jackson Laboratory