Phenotypes Associated with This Genotype

Genotype
MGI:3692746

• Allelic Composition: Gfap^tm2Mes/Gfap⁺; Tg(GFAP)10Mes/0
• Genetic Background: involves: 129S6/SvEvTac * 129S7/SvEvBrd * FVB/N

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

mortality/aging

premature death ( J:114689 )

• almost all die at around 30 days of age

nervous system

seizures ( J:114689 )

• two mutants exhibit seizure-like episodes before death

abnormal astrocyte morphology ( J:114689 )

• at 24 days of age, exhibit increased Rosenthal fiber formation and higher levels of insoluble Gfap than either single mutant

• astrocytes are hypertrophied in the regions of brain that normally show high levels of Gfap expression

behavior/neurological

seizures ( J:114689 )

• two mutants exhibit seizure-like episodes before death

Mouse Models of Human Disease		DO ID	OMIM ID(s)	Ref(s)
Alexander disease		DOID:4252	OMIM:203450	J:114689