nervous system
• mice have higher levels of total A-beta protein and the cleaved A-beta 1-42(43) peptide than Tg(APP)8.9Btla mice, but levels are lower than those in Tg(APPSwLon)96Btla mice
(J:42613)
• mice have 7- to 8-fold higher levels of Abeta1-42 peptide in their brains compared to Tg(PSEN1H163R)G9Btla hemizygotes
(J:58050)
• diffuse amyloid beta deposits are detected in the hippocampus and frontal cortex at 24-26 months of age
(J:58050)
|
homeostasis/metabolism
• mice have higher levels of total A-beta protein and the cleaved A-beta 1-42(43) peptide than Tg(APP)8.9Btla mice, but levels are lower than those in Tg(APPSwLon)96Btla mice
(J:42613)
• mice have 7- to 8-fold higher levels of Abeta1-42 peptide in their brains compared to Tg(PSEN1H163R)G9Btla hemizygotes
(J:58050)
• diffuse amyloid beta deposits are detected in the hippocampus and frontal cortex at 24-26 months of age
(J:58050)
|
Mouse Models of Human Disease |
DO ID | OMIM ID(s) | Ref(s) | |
Alzheimer's disease | DOID:10652 | J:42613 |