Phenotypes Associated with This Genotype

Genotype
MGI:3693439

• Allelic Composition: Tg(APPSw)40Btla/0
• Genetic Background: involves: 129S1/Sv * 129X1/SvJ

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

nervous system

amyloid beta deposits ( J:42613 , J:58050 )

• mice have higher levels of total A-beta protein and the cleaved A-beta 1-42(43) peptide than Tg(APP)8.9Btla mice, but levels are lower than those in Tg(APPSwLon)96Btla mice (J:42613)

• mice have 7- to 8-fold higher levels of Abeta1-42 peptide in their brains compared to Tg(PSEN1H163R)G9Btla hemizygotes (J:58050)

• diffuse amyloid beta deposits are detected in the hippocampus and frontal cortex at 24-26 months of age (J:58050)

homeostasis/metabolism

amyloid beta deposits ( J:42613 , J:58050 )

• mice have higher levels of total A-beta protein and the cleaved A-beta 1-42(43) peptide than Tg(APP)8.9Btla mice, but levels are lower than those in Tg(APPSwLon)96Btla mice (J:42613)

• mice have 7- to 8-fold higher levels of Abeta1-42 peptide in their brains compared to Tg(PSEN1H163R)G9Btla hemizygotes (J:58050)

• diffuse amyloid beta deposits are detected in the hippocampus and frontal cortex at 24-26 months of age (J:58050)

Mouse Models of Human Disease		DO ID	OMIM ID(s)	Ref(s)
Alzheimer's disease		DOID:10652		J:42613