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Phenotypes Associated with This Genotype
Genotype
MGI:3693680
Allelic
Composition		 Fbxo11Jf/Fbxo11Mutt
Genetic
Background		 involves: BALB/c * C3H/HeN
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Fbxo11Jf mutation (2 available); any Fbxo11 mutation (52 available)
Fbxo11Mutt mutation (0 available); any Fbxo11 mutation (52 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
mortality/aging
neonatal lethality, incomplete penetrance ( J:114851 )
• a small proportion (12%) of compound heterozygous showed perinatal lethality similar to Fbxo11Jf/Fbxo11Jf or similar to Fbxo11Mutt/Fbxo11Mutt

hearing/vestibular/ear
impaired hearing ( J:114851 )
• reduced hearing in response to a click box similar to Fbxo11Jf heterozygotes
increased susceptibility to otitis media ( J:114851 )
• similar to Fbxo11Jf/Fbxo11+

immune system
increased susceptibility to otitis media ( J:114851 )
• similar to Fbxo11Jf/Fbxo11+

craniofacial
short face ( J:114851 )
• shortened face similar to Fbxo11Jf/Fbxo11+
midline facial cleft ( J:114851 )
• in some similar to Fbxo11Jf/Fbxo11Jf or similar to Fbxo11Mutt/Fbxo11Mutt

growth/size/body
short face ( J:114851 )
• shortened face similar to Fbxo11Jf/Fbxo11+
midline facial cleft ( J:114851 )
• in some similar to Fbxo11Jf/Fbxo11Jf or similar to Fbxo11Mutt/Fbxo11Mutt

Mouse Models of Human Disease
 DO ID OMIM ID(s) Ref(s)
otitis media DOID:10754 J:114851

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
11/12/2024
MGI 6.24 		The Jackson Laboratory