About   Help   FAQ
Phenotypes Associated with This Genotype
Genotype
MGI:3693680
Allelic
Composition		 Fbxo11Jf/Fbxo11Mutt
Genetic
Background		 involves: BALB/c * C3H/HeN
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Fbxo11Jf mutation (2 available); any Fbxo11 mutation (52 available)
Fbxo11Mutt mutation (0 available); any Fbxo11 mutation (52 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
mortality/aging
neonatal lethality, incomplete penetrance ( J:114851 )
• a small proportion (12%) of compound heterozygous showed perinatal lethality similar to Fbxo11Jf/Fbxo11Jf or similar to Fbxo11Mutt/Fbxo11Mutt

hearing/vestibular/ear
impaired hearing ( J:114851 )
• reduced hearing in response to a click box similar to Fbxo11Jf heterozygotes
increased susceptibility to otitis media ( J:114851 )
• similar to Fbxo11Jf/Fbxo11+

immune system
increased susceptibility to otitis media ( J:114851 )
• similar to Fbxo11Jf/Fbxo11+

craniofacial
short face ( J:114851 )
• shortened face similar to Fbxo11Jf/Fbxo11+
midline facial cleft ( J:114851 )
• in some similar to Fbxo11Jf/Fbxo11Jf or similar to Fbxo11Mutt/Fbxo11Mutt

growth/size/body
short face ( J:114851 )
• shortened face similar to Fbxo11Jf/Fbxo11+
midline facial cleft ( J:114851 )
• in some similar to Fbxo11Jf/Fbxo11Jf or similar to Fbxo11Mutt/Fbxo11Mutt

Mouse Models of Human Disease
 DO ID OMIM ID(s) Ref(s)
otitis media DOID:10754 J:114851

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
Warranty Disclaimer, Privacy Notice, Licensing, & Copyright
Send questions and comments to User Support. 		last database update
12/17/2024
MGI 6.24 		The Jackson Laboratory