Phenotypes Associated with This Genotype

Genotype
MGI:3694693

hm1

• Allelic Composition: Cyp4a14^tm1Jhc/Cyp4a14^tm1Jhc
• Genetic Background: involves: 129S6/SvEvTac * 129X1/SvJ

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

cardiovascular system

abnormal renal vascular resistance ( J:77631 )

• reduced autoregulatory efficiency of kidney microvasculature

increased renal vascular resistance ( J:77631 )

♂ • decreased preglomerular arteriolar diameter in males

decreased systemic arterial blood pressure ( J:77631 )

♂ • castration reduces high blood pressure of males to normal levels

increased systemic arterial blood pressure ( J:77631 )

• increased mean blood pressure in males

• increased blood pressure is spontaneous and insensitive to dietary salt

• female blood pressure shows less elevation and is more comparable to wild-type male blood pressure

• testosterone or dihydrotestosterone administration increases blood pressure of females and castrated males

increased systemic arterial diastolic blood pressure ( J:77631 )

♂ • in males

increased systemic arterial systolic blood pressure ( J:77631 )

♂ • in males

renal/urinary system

abnormal renal vascular resistance ( J:77631 )

• reduced autoregulatory efficiency of kidney microvasculature

increased renal vascular resistance ( J:77631 )

♂ • decreased preglomerular arteriolar diameter in males

homeostasis/metabolism

abnormal lipid homeostasis ( J:77631 )

• significantly higher rates of conversion of arachidonic acid to 20-hydroxyarachidonic acid in male kidneys due to up regulation of Cyp4a12

• little 20-hydroxyarachidonic acid activity on female kidneys

• castration reduces conversion of arachidonic acid to 20-hydroxyarachidonic acid in male kidneys