Phenotypes for Tg(Syn1-ADCY7)11004Btab MGI:3695130 MGI Mouse

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Phenotypes Associated with This Genotype

Allelic Composition	Tg(Syn1-ADCY7)11004Btab/0
Genetic Background	involves: C57BL/6 * SJL

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Using the International Mouse Strain Resource (IMSR)
No mouse lines available in IMSR.
See publication links below for author information.

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

behavior/neurological

abnormal behavioral response to xenobiotic ( J:116797 )

• develop greater morphine tolerance with low levels of chronic daily treatment (5mg/kg) and with higher morphine concentrations (10 mg/kg) develop tolerance earlier compared to wild-type mice

increased chemically-elicited antinociception ( J:116797 )

• significantly lower morphine ED50 in the hot plate test; however, basal paw-lick latency is similar to wild-type mice

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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