Phenotypes Associated with This Genotype

Genotype
MGI:3695610

• Allelic Composition: Satb2^tm1(cre)Vit/Satb2⁺
• Genetic Background: involves: C57BL/6

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

mortality/aging

preweaning lethality, incomplete penetrance ( J:116770 )

• fewer found at weaning than expected (about 35% compared to the expected 50%)

craniofacial

abnormal jaw morphology ( J:116770 )

• at E11.5 a variable increase in apoptosis is seen in the mandibular BA1, maxillary BA1, and frontonasal mesenchyme regions that normally express Satb2

abnormal incisor morphology ( J:116770 )

• variable incisor hypodontia and or adontia

premaxilla hypoplasia ( J:116770 )

abnormal nasal capsule morphology ( J:116770 )

• hypoplasia

decreased mouth size ( J:116770 )

• small mouth

cleft palate ( J:116770 )

• seen in about 1/4 of mice

asymmetric snout ( J:116770 )

• snout is occasionally asymmetric

short snout ( J:116770 )

• snout is strongly truncated

respiratory system

abnormal nasal capsule morphology ( J:116770 )

• hypoplasia

skeleton

abnormal jaw morphology ( J:116770 )

• at E11.5 a variable increase in apoptosis is seen in the mandibular BA1, maxillary BA1, and frontonasal mesenchyme regions that normally express Satb2

abnormal incisor morphology ( J:116770 )

• variable incisor hypodontia and or adontia

premaxilla hypoplasia ( J:116770 )

abnormal nasal capsule morphology ( J:116770 )

• hypoplasia

digestive/alimentary system

cleft palate ( J:116770 )

• seen in about 1/4 of mice

growth/size/body

abnormal incisor morphology ( J:116770 )

• variable incisor hypodontia and or adontia

abnormal nasal capsule morphology ( J:116770 )

• hypoplasia

decreased mouth size ( J:116770 )

• small mouth

cleft palate ( J:116770 )

• seen in about 1/4 of mice

asymmetric snout ( J:116770 )

• snout is occasionally asymmetric

short snout ( J:116770 )

• snout is strongly truncated

microcephaly ( J:116770 )

• slight

Mouse Models of Human Disease		DO ID	OMIM ID(s)	Ref(s)
isolated cleft palate		DOID:0110213	OMIM:119540	J:116770