Phenotypes Associated with This Genotype

Genotype
MGI:3695720

• Allelic Composition: Krt4^Bcc1/Krt4⁺
• Genetic Background: C3HeB/FeJ-Krt4^Bcc1

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

digestive/alimentary system

oral leukoplakia ( J:116740 )

• on the tongue

• milder than in homozygous mice

abnormal tongue morphology ( J:116740 )

• thickened lingual mucosa with evidence of inter-papillar cytolysis

pigmentation

diluted coat color ( J:116740 )

• bright coat color and light brown pigment in all hairs rather than the normal dark brown/black

• difference in coat color is most visible around 4 weeks of age

craniofacial

oral leukoplakia ( J:116740 )

• on the tongue

• milder than in homozygous mice

abnormal tongue morphology ( J:116740 )

• thickened lingual mucosa with evidence of inter-papillar cytolysis

integument

diluted coat color ( J:116740 )

• bright coat color and light brown pigment in all hairs rather than the normal dark brown/black

• difference in coat color is most visible around 4 weeks of age

growth/size/body

oral leukoplakia ( J:116740 )

• on the tongue

• milder than in homozygous mice

abnormal tongue morphology ( J:116740 )

• thickened lingual mucosa with evidence of inter-papillar cytolysis

Mouse Models of Human Disease		DO ID	OMIM ID(s)	Ref(s)
white sponge nevus		DOID:0050448	OMIM:PS193900	J:116740