Phenotypes Associated with This Genotype

Genotype
MGI:3695903

• Allelic Composition: Pparg^tm1Avp/Pparg⁺
• Genetic Background: involves: 129S2/SvPas * C57BL/6

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

cellular

abnormal fat cell differentiation ( J:116568 )

• in vitro differentiation of preadipocytes is impaired

homeostasis/metabolism

homeostasis/metabolism phenotype ( J:116568 )

N • on a normal chow or high fat diet insulin sensitivity is similar to wild-type mice unlike human patients with the same mutation

decreased circulating adiponectin level ( J:116568 )

• reduced serum adiponectin level

abnormal lipid homeostasis ( J:116568 )

• impaired clearance of triglycerides and fatty acids in an oral lipid load test

abnormal triglyceride level ( J:116568 )

increased circulating triglyceride level ( J:116568 )

• in mice on a high fat diet

growth/size/body

growth/size/body region phenotype ( J:116568 )

N • on a normal chow or high fat diet body mass is similar to wild-type mice unlike human patients with the same mutation

increased liver weight ( J:116568 )

• in mice on a high fat diet compared to wild-type mice on the same diet

adipose tissue

abnormal adipose tissue distribution ( J:116568 )

• decreased ratio of gonadal white adipose tissue to inguinal subcutaneous white adipose tissue; however total body fat is similar to wild-type

abnormal fat cell differentiation ( J:116568 )

• in vitro differentiation of preadipocytes is impaired

liver/biliary system

increased liver weight ( J:116568 )

• in mice on a high fat diet compared to wild-type mice on the same diet

hepatic steatosis ( J:116568 )

• on a high fat diet but not when fed a normal chow diet

Mouse Models of Human Disease		DO ID	OMIM ID(s)	Ref(s)
NOT	familial partial lipodystrophy	DOID:0050440	OMIM:PS151660	J:116568