Phenotypes Associated with This Genotype

Genotype
MGI:3695904

• Allelic Composition: Lep^ob/Lep^ob; Pparg^tm1Avp/Pparg⁺
• Genetic Background: involves: 129S2/SvPas * C57BL/6

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

homeostasis/metabolism

increased circulating triglyceride level ( J:116568 )

• increased compared to mice that are wild-type at the Lep locus and on a high fat diet

abnormal glucose homeostasis ( J:116568 )

increased circulating glucose level ( J:116568 )

• increased at 4 weeks of age in fed mice relative to Lep^ob homozygotes and wild-type mice

increased circulating insulin level ( J:116568 )

• not significantly different from Lep^ob homozygotes, but increased compared to wild-type mice

insulin resistance ( J:116568 )

• increased relative to Lep^ob homozygotes

decreased circulating adiponectin level ( J:116568 )

• reduced plasma adiponectin levels, independent of presence or absence of the Lep^ob allele

growth/size/body

decreased body fat mass ( J:116568 )

• at 12 weeks of age fat mass is reduced relative to Lep^ob homozygotes

decreased body weight ( J:116568 )

• at 5 weeks of age body mass is decreased relative to Lep^ob homozygotes, but is still higher than in wild-type mice

• at 12 weeks of age body mass is reduced by 14% and 12 % in females and males, respectively, relative to Lep^ob homozygotes

increased liver weight ( J:116568 )

• at 12 weeks of age relative to Lep^ob homozygotes

adipose tissue

abnormal white adipose tissue amount ( J:116568 )

• reduced amount of gonadal and subcutaneous white fat relative to Lep^ob homozygotes

decreased body fat mass ( J:116568 )

• at 12 weeks of age fat mass is reduced relative to Lep^ob homozygotes

decreased fat cell size ( J:116568 )

• smaller adipocytes in the gonadal and subcutaneous white fat relative to Lep^ob homozygotes

abnormal gonadal fat pad morphology ( J:116568 )

• reduced amount relative to Lep^ob homozygotes

liver/biliary system

increased liver weight ( J:116568 )

• at 12 weeks of age relative to Lep^ob homozygotes

hepatic steatosis ( J:116568 )

• at 12 weeks of age relative to Lep^ob homozygotes

muscle

abnormal skeletal muscle morphology ( J:116568 )

• reduced intramyocellular lipid deposition relative to Lep^ob homozygotes

behavior/neurological

polyphagia ( J:116568 )

• not significantly different from Lep^ob homozygotes

Mouse Models of Human Disease		DO ID	OMIM ID(s)	Ref(s)
familial partial lipodystrophy		DOID:0050440	OMIM:PS151660	J:116568