Phenotypes Associated with This Genotype

Genotype
MGI:3696575

• Allelic Composition: Tg(APP695)3Dbo/0
• Genetic Background: B6.C3-Tg(APP695)3Dbo

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

nervous system

amyloid beta deposits ( J:109847 )

• in mice 26 months old, moderate levels of amyloid deposits in brains are observed in mice backcrossed 5-7 generations

• mice 12-13 months old that have been backcrossed 10 generations have slightly higher accumulations than Tg(APP695)3Dbo mice

• old (<24 months) animals backcrossed either 5-7 or 10 times to B6 have significantly higher levels of amyloid Abeta in their brains than adult (~9.6 months) or middle aged (13-15 months) animals

behavior/neurological

abnormal motor capabilities/coordination/movement ( J:109847 )

• at 24 months, males display a mild deterioration of sensorimotor abilities

increased startle reflex ( J:109847 )

• mice backcrossed 10 generations have higher reactivity to acoustic stimuli compared to wild-type

abnormal locomotor behavior ( J:109847 )

• in radial maze testing, male mutants backcrossed 5-7 generations show high motor reactivity compared to females or control animals, and entered the closest arm of the maze which prevented them from learning the task

homeostasis/metabolism

amyloid beta deposits ( J:109847 )

• in mice 26 months old, moderate levels of amyloid deposits in brains are observed in mice backcrossed 5-7 generations

• mice 12-13 months old that have been backcrossed 10 generations have slightly higher accumulations than Tg(APP695)3Dbo mice

• old (<24 months) animals backcrossed either 5-7 or 10 times to B6 have significantly higher levels of amyloid Abeta in their brains than adult (~9.6 months) or middle aged (13-15 months) animals

Mouse Models of Human Disease		DO ID	OMIM ID(s)	Ref(s)
Alzheimer's disease		DOID:10652		J:109847
Alzheimer's disease 4		DOID:0110040	OMIM:606889	J:109847