Phenotypes Associated with This Genotype

Genotype
MGI:3697474

• Allelic Composition: Bin1^tm1Gcp/Bin1^tm2Gcp; Tg(MMTV-Myc)141-3Led/0; Tg(Wap-cre)11738Mam/0
• Genetic Background: involves: 129S6/SvEvTac * C57BL/6 * CD-1 * FVB/N * SJL

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

neoplasm

increased mammary adenocarcinoma incidence ( J:117330 )

increased lymphoma incidence ( J:117330 )

• some mice develop aggressive lymphomas which occasionally appear before mammary carcinomas

cellular

abnormal cell physiology ( J:117330 )

• tumor cells show increased motility in monolayer culture

decreased apoptosis ( J:117330 )

• tumor cells in culture show several fold greater resistance to serum deprivation-induced apoptosis

increased cell proliferation ( J:117330 )

• tumor cells show 3-4 fold higher rates of proliferation under anchorage-dependent conditions

homeostasis/metabolism

abnormal enzyme/coenzyme activity ( J:117330 )

• tumor cells have higher gelatinase activity

endocrine/exocrine glands

increased mammary adenocarcinoma incidence ( J:117330 )

integument

increased mammary adenocarcinoma incidence ( J:117330 )

Mouse Models of Human Disease		DO ID	OMIM ID(s)	Ref(s)
breast cancer		DOID:1612	OMIM:114480	J:117730