Phenotypes Associated with This Genotype

Genotype
MGI:3697915

tg15

• Allelic Composition: Tg(BCL2)22Wehi/0
• Genetic Background: involves: C57BL/6JWehi * SJL/JWehi

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

hematopoietic system

abnormal B cell differentiation ( J:93111 )

• most transgenic B cells are smaller than normal B cells

increased B cell number ( J:93111 )

• mutants show a 2- to 5-fold excess of B lymphocytes in spleen, lymph nodes, and bone marrow

abnormal B cell physiology ( J:93111 )

• transgenic spleen B cells show prolonged in vitro survival in culture compared to wild-type splenocytes

immune system

abnormal B cell differentiation ( J:93111 )

• most transgenic B cells are smaller than normal B cells

increased B cell number ( J:93111 )

• mutants show a 2- to 5-fold excess of B lymphocytes in spleen, lymph nodes, and bone marrow

abnormal B cell physiology ( J:93111 )

• transgenic spleen B cells show prolonged in vitro survival in culture compared to wild-type splenocytes

increased susceptibility to autoimmune disorder ( J:93111 )

• a portion of transgenic mice develop autoimmune-like disease