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Phenotypes Associated with This Genotype
Genotype
MGI:3698301
cn16
Allelic
Composition		 Hif1atm3Rsjo/Hif1atm3Rsjo
Tg(Lck-cre)1Jtak/0
Genetic
Background		 involves: 129S1/Sv * 129X1/SvJ
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Hif1atm3Rsjo mutation (3 available); any Hif1a mutation (50 available)
Tg(Lck-cre)1Jtak mutation (3 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
immune system
increased interferon-gamma secretion ( J:117857 )
• exhibit higher IFN-gamma secretion by activated splenocytes
• both CD4+ and CD8+ T cells produce higher levels or IFN-gamma upon activation

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
12/17/2024
MGI 6.24 		The Jackson Laboratory