Phenotypes for Gba1 Lyz2 MGI:3699187 MGI Mouse

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Phenotypes Associated with This Genotype

Allelic Composition	Gba1^tm1Clk/Gba1^tm1.1Clk Lyz2^tm1(cre)Ifo/Lyz2⁺
Genetic Background	involves: 129P2/OlaHsd * 129S1/Sv * 129X1/SvJ * C57BL/6J

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Gba1^tm1.1Clk mutation (2 available); any Gba1 mutation (47 available)
Gba1^tm1Clk mutation (1 available); any Gba1 mutation (47 available)
Lyz2^tm1(cre)Ifo mutation (14 available); any Lyz2 mutation (40 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

homeostasis/metabolism

abnormal enzyme/coenzyme activity ( J:117763 )

• tissue glucocerebrosidase activity is reduced to ~30-50% of control levels in all tissues

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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