Phenotypes Associated with This Genotype

Genotype
MGI:3700223

cx3

• Allelic Composition: Cd72^tm1Jrp/Cd72^tm1Jrp; Tg(BCL2)22Wehi/0
• Genetic Background: either: (involves: 129P2/OlaHsd * C57BL/6JWehi * SJL/JWehi) or (involves: 129P2/OlaHsd * C57BL/6 * C57BL/6JWehi * SJL/JWehi)

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

immune system

increased immature B cell number ( J:76990 )

• increase in the frequency of immature B cells in the spleen and bone marrow

decreased mature B cell number ( J:76990 )

• reduction in the frequency of mature B cells in the spleen and bone marrow

abnormal B cell physiology ( J:76990 )

• mice show only partial correction of B cell maturation defect and have reduced numbers of mature B cells

hematopoietic system

increased immature B cell number ( J:76990 )

• increase in the frequency of immature B cells in the spleen and bone marrow

decreased mature B cell number ( J:76990 )

• reduction in the frequency of mature B cells in the spleen and bone marrow

abnormal B cell physiology ( J:76990 )

• mice show only partial correction of B cell maturation defect and have reduced numbers of mature B cells