Phenotypes Associated with This Genotype

Genotype
MGI:3700827

cn11

• Allelic Composition: Foxa2^tm1Khk/Foxa2^tm1Khk; Tg(Foxa3-cre)1Khk/0
• Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * CD-1 * DBA

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

mortality/aging

postnatal lethality, complete penetrance ( J:96332 )

• most die by P3, with a few surviving to P5

growth/size/body

decreased body size ( J:96332 )

endocrine/exocrine glands

decreased pancreatic alpha cell number ( J:96332 )

• the number of mature glucagon-positive pancreatic alpha-cells is reduced

disorganized pancreatic islets ( J:96332 )

• islets are irregularly shaped and display a disorganized architecture with many small clusters of endocrine cells embedded in the exocrine tissue

homeostasis/metabolism

hypoglycemia ( J:96332 )

• severely hypoglycemic

decreased circulating glucagon level ( J:96332 )

• 50% reduction of plasma glucagon

integument

decreased skin turgor ( J:96332 )