Phenotypes Associated with This Genotype

Genotype
MGI:3700959

hm1

• Allelic Composition: Fos^tm1Wag/Fos^tm1Wag
• Genetic Background: involves: 129S2/SvPas

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

mortality/aging

perinatal lethality, incomplete penetrance ( J:65766 )

• mice exhibit reduced viability at birth

skeleton

skeleton phenotype ( J:118753 )

N • when mice are transplanted with Nfatc1^tm1Mak, osteopetrosis is ameliorated and bone marrow cavities are observed

failure of tooth eruption ( J:65766 )

decreased osteoclast cell number ( J:65766 )

• absent

abnormal bone marrow cavity morphology ( J:65766 )

• absent

osteopetrosis ( J:65766 )

behavior/neurological

behavior/neurological phenotype ( J:109459 )

N • genetic deficiency of Fos does not impair development of long-term memory in aversive taste learning; acute suppression of Fos expression does cause impairment

growth/size/body

failure of tooth eruption ( J:65766 )

decreased body size ( J:65766 )

• at 6 weeks

decreased fetal size ( J:65766 )

• mice are small at birth

vision/eye

decreased retina apoptosis ( J:65766 )

• mice exhibit resistance to light-induced retinal cell apoptosis unlike wild-type mice

craniofacial

craniofacial phenotype ( J:118753 )

N • when mice are transplanted with Nfatc1^tm1Mak, tooth eruption is observed

failure of tooth eruption ( J:65766 )

hematopoietic system

decreased osteoclast cell number ( J:65766 )

• absent

immune system

decreased osteoclast cell number ( J:65766 )

• absent

cellular

decreased retina apoptosis ( J:65766 )

• mice exhibit resistance to light-induced retinal cell apoptosis unlike wild-type mice