Analysis Tools
growth/size/body
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• incisors and molars are present but obstructed by abnormal amounts of bone
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absent teeth
(
J:3493
)
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• mutants lack teeth
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short snout
(
J:3493
)
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• 10 days after birth, body weight is reduced ~40-60% compared to wild-type
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limbs/digits/tail
short limbs
(
J:3493
)
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• homozygotes have much shorter limbs than littermates
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skeleton
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• incisors and molars are present but obstructed by abnormal amounts of bone
|
absent teeth
(
J:3493
)
|
• mutants lack teeth
|
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• longitudinal columns of proliferative zone are irregular; zone of proliferating chondrocytes is greatly reduced
• this is observed in all bones examined
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• zone of hypertrophic chondrocytes is increased
• this is observed in all bones examined
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• much broader than wild-type
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• much broader than wild-type
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• bone cavities of long bone appear to be calcified
• cavities are occupied by abundant bone and cartilage trabeculae which reduce the effective bone marrow cavity by ~80%
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• osteoblastic cells are absent along both the periosteal and endosteal cortical surfaces
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• cortical bone is extremely thin and underdeveloped
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• cavities are occupied by abundant bone and cartilage trabeculae which reduce the effective bone marrow cavity by ~80%
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osteopetrosis
(
J:3493
)
|
• this is the predominant phenotype in mutant mice
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craniofacial
|
• incisors and molars are present but obstructed by abnormal amounts of bone
|
absent teeth
(
J:3493
)
|
• mutants lack teeth
|
short snout
(
J:3493
)
hematopoietic system
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• in 4-6 week old mice, size of thymus is reduced
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• total number of thymocytes is reduced by 90%
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• frequency of double positive immature thymocytes is decreased >90% in 4-6 week-old mice
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• there is a 75% reduction in B220+ B cells in the spleen in 4-6 week-old mice
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• in thymus there is 6-7-fold increase in CD3+ T cells bearing CD4+ or CD8+ in 4-6 week-old mice
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• mutant spleens have a poorly organized cortex and medulla
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• spleens show less dense white pulp in 4-6 week-old mice in 4-6 week-old mice
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• total number of splenocytes is reduced by 25%
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• macrophages show enhanced NF kappaB phosphorylation after Salmonella enterica serovar Typhimurium infection than wild-type cells
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• macrophages show increased apoptotic death after Salmonella enterica serovar Typhimurium infection than wild-type cells
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• macrophages show enhanced proinflammatory cytokine production after Salmonella enterica serovar Typhimurium infection than wild-type cells
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immune system
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• in 4-6 week old mice, size of thymus is reduced
|
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• total number of thymocytes is reduced by 90%
|
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• frequency of double positive immature thymocytes is decreased >90% in 4-6 week-old mice
|
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• there is a 75% reduction in B220+ B cells in the spleen in 4-6 week-old mice
|
|
• in thymus there is 6-7-fold increase in CD3+ T cells bearing CD4+ or CD8+ in 4-6 week-old mice
|
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• mutant spleens have a poorly organized cortex and medulla
|
|
• spleens show less dense white pulp in 4-6 week-old mice in 4-6 week-old mice
|
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• total number of splenocytes is reduced by 25%
|
|
• macrophages show enhanced NF kappaB phosphorylation after Salmonella enterica serovar Typhimurium infection than wild-type cells
|
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• macrophages show increased apoptotic death after Salmonella enterica serovar Typhimurium infection than wild-type cells
|
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• macrophages show enhanced proinflammatory cytokine production after Salmonella enterica serovar Typhimurium infection than wild-type cells
|
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• mutant macrophages show enhanced production of proinflammatory cytokines after Salmonella enterica serovar Typhimurium infection
|
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• Fos-deficient mice are more susceptible to Salmonella infection
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reproductive system
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• there is distorted female transmission frequency; heterozygous males mated to wild-type produce 51% heterozygous offspring, while heterozygous females mated to wild-type males produce only 34% heterozygous pups
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cellular
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• macrophages show increased apoptotic death after Salmonella enterica serovar Typhimurium infection than wild-type cells
|
endocrine/exocrine glands
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• in 4-6 week old mice, size of thymus is reduced
|
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• total number of thymocytes is reduced by 90%
|
