Phenotypes Associated with This Genotype

Genotype
MGI:3700989

cx4

• Allelic Composition: Fos^tm1Wag/Fos^tm1Wag; Trp53^tm1Tyj/Trp53^tm1Tyj
• Genetic Background: involves: 129S2/SvPas * C57BL/6

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

skeleton

osteopetrosis ( J:89283 )

• double mutants display similar osteopetrotic phenotype to Fos^tm1Wag mice

neoplasm

increased rhabdomyosarcoma incidence ( J:89283 )

• at 10 weeks of age, double mutants develop facial and orbital tumors with penetrance of 93% at 25 weeks of age

• tumors are polygonal or elongated with pleomorphic nuclei and eosinophilic cytoplasm with cross-striations

• tumors display invasive growth into facial and external orbital muscles

muscle

increased rhabdomyosarcoma incidence ( J:89283 )

• at 10 weeks of age, double mutants develop facial and orbital tumors with penetrance of 93% at 25 weeks of age

• tumors are polygonal or elongated with pleomorphic nuclei and eosinophilic cytoplasm with cross-striations

• tumors display invasive growth into facial and external orbital muscles