Phenotypes Associated with This Genotype

Genotype
MGI:3701210

hm1

• Allelic Composition: Ptgs2^{tm2(Ptgs1)Fun}/Ptgs2^{tm2(Ptgs1)Fun}
• Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

mortality/aging

preweaning lethality, incomplete penetrance ( J:118171 )

• only 16.5% of pups are identified as homozygous at 10-12 days, in contrast to 25% expected

immune system

abnormal macrophage physiology ( J:118171 )

• upon LPS stimulation, induced mutant macrophages do not produce detectable prostaglandin E2 (PGE2)

hematopoietic system

abnormal macrophage physiology ( J:118171 )

• upon LPS stimulation, induced mutant macrophages do not produce detectable prostaglandin E2 (PGE2)